"Sisters" followed in the vein of other adult dramas like "Thirtysomething." It made it's debut in May, 1991 and continued on for another 5 seasons. It was created by the team who later went on to remake "Queer as Folk" for America.
It took place in Winnetka, Illinois, which is the fanciest of the five fancy hamlets that comprise Chicago's North Shore. Lots of memorable movies take place in those wealthy, icy suburbs like "Home Alone," "Ferris Bueller's Day Off," and "Ordinary People."
"Sisters" followed the lives of the Reed family, a family of all girls, and their complex, convoluted relationships. It featured superstar sensation Swoosie Kurtz alongside other big names like Sela Ward and Sheila Kelley, as well as future stars like George Clooney, Paul Rudd and Kirsten Dunst.